Equity-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2017

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of details regarding stock options granted under equity incentive plans

The following table summarizes stock option activity for the three months ended March 31, 2017:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2016	2,158,822		5,200	134,181		814,975		3,113,178
Granted	322,210		—	—		—		322,210
Exercised	(9,065	)	—	—		—		(9,065	)
Expired or terminated	(50,696	)	—	(281	)	(27,625	)	(78,602	)
Outstanding at March 31, 2017	2,421,271		5,200	133,900		787,350		3,347,721

Summary of details regarding restricted stock units granted under equity incentive plans

The following table summarizes RSU activity for the three months ended March 31, 2017:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2016	773,804		—	27,694		135,456		936,954
Granted	732,956		—	—		—		732,956
Vested	(143,056	)	—	(11,664	)	(1,000	)	(155,720	)
Expired or terminated	(26,957	)	—	(501	)	(5,318	)	(32,776	)
Outstanding at March 31, 2017	1,336,747		—	15,529		129,138		1,481,414

Schedule of equity-based compensation expense

Equity-based compensation expense for the three months ended March 31, 2017 and 2016 consisted of the following (in thousands):

	Three Months Ended March 31,
	2017			2016
Cost of product sales	$	129		$	320
Research and development	756			756
Selling, general and administrative	4,893			5,084
Total equity-based compensation expense	5,778			6,160
Income tax effect	(1,605		)	(1,674		)
After-tax effect of equity-based compensation expense	$	4,173		$	4,486