Income Taxes - Deferred Tax Components (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Assets
Net operating loss carryforwards	$ 116,275	$ 172,944
Tax credit carryforwards	9,415	6,262
Deferred revenue	1,811	626
Equity-based compensation expense	8,045	5,464
Capitalized research & development	18,284	25,216
Reserves	8,018	8,900
Contingent consideration	4,140	1,258
Other	9,769	9,636
Liabilities
Property, plant and equipment depreciation	(2,145)	(2,844)
Intangible assets and inventory	(367,667)	(400,357)
Debt instruments	(1,040)	(1,213)
Other	(542)	(3,178)
Deferred tax liabilities net of deferred tax assets	(195,637)	(177,286)
Valuation allowance	(1,429)	(11,859)
Net deferred tax liabilities	$ (197,066)	$ (189,145)