Income Taxes - Narrative (Details) - USD ($)	3 Months Ended	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Tax Credit Carryforward [Line Items]
Income tax expense (benefit)		$ 11,538,000	$ 7,065,000	$ (153,159,000)
Effective tax rate	127.40%	127.40%	17.70%	883.20%
Statutory federal tax rate		35.00%	35.00%	34.00%
Decrease in valuation allowance		$ 10,400,000
Operating loss carryforwards	$ 1,500,000	1,500,000
Net operating loss carryforwards	116,275,000	116,275,000	$ 172,944,000
Unrecognized tax benefits	13,330,000	13,330,000	12,695,000	$ 0	$ 0
Unrecognized tax benefits that would impact effective tax rate	13,000,000	13,000,000	12,400,000	0
Additions based on tax positions related to the current year		600,000
Lumara Health
Tax Credit Carryforward [Line Items]
Income tax expense (benefit)				$ (153,200,000)
CBR
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	20,100,000	20,100,000
Research Tax Credit Carryforward | Lumara Health
Tax Credit Carryforward [Line Items]
Unrecognized tax benefits			$ 12,700,000
State and Local Jurisdiction
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	122,000,000	122,000,000
Net operating loss carryforwards	33,200,000	33,200,000
Tax credit carryforward, amount	1,200,000	1,200,000
State and Local Jurisdiction | Lumara Health
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	19,600,000	19,600,000
Internal Revenue Service (IRS)
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	377,600,000	377,600,000
Net operating loss carryforwards	58,300,000	58,300,000
Tax credit carryforward, amount	8,600,000	8,600,000
Internal Revenue Service (IRS) | Lumara Health
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	281,100,000	281,100,000
Tax credit carryforward, amount	$ 1,500,000	$ 1,500,000