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Fair Value Measurements - Contingent Consideration (Details) - USD ($)
3 Months Ended 12 Months Ended
Nov. 12, 2014
Jun. 30, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Reconciliation of contingent consideration obligations related to acquisitions          
Adjustments to fair value of contingent consideration     $ 25,683,000 $ 4,271,000 $ (681,000)
Change in fair value of contingent consideration     25,683,000 4,271,000 (681,000)
CBR          
Acquired Finite-Lived Intangible Assets [Line Items]          
Contingent consideration classified as short-term liability     0    
Lumara Health and MuGard Rights | Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)          
Reconciliation of contingent consideration obligations related to acquisitions          
Balance at beginning of period     222,559,000 218,702,000  
Payments made     (100,246,000) (456,000)  
Adjustments to fair value of contingent consideration     25,682,000 4,271,000  
Other adjustments       42,000  
Balance at end of period     147,995,000 222,559,000 $ 218,702,000
Change in fair value of contingent consideration     25,682,000 $ 4,271,000  
Lumara Health          
Acquired Finite-Lived Intangible Assets [Line Items]          
Contingent consideration classified as short-term liability     96,800,000    
Reconciliation of contingent consideration obligations related to acquisitions          
Adjustments to fair value of contingent consideration     31,100,000    
Change in fair value of contingent consideration     $ 31,100,000    
Discount rate (percent) 5.00%   5.00%    
Estimated undiscounted milestone amounts payable     $ 250,000,000    
MuGard          
Acquired Finite-Lived Intangible Assets [Line Items]          
Contingent consideration classified as short-term liability     300,000    
Reconciliation of contingent consideration obligations related to acquisitions          
Adjustments to fair value of contingent consideration   $ (5,600,000) (5,400,000)    
Change in fair value of contingent consideration   $ (5,600,000) $ (5,400,000)    
Discount rate (percent)     11.00%    
Period over which estimated undiscounted royalty amounts could be paid (in years)     10 years    
MuGard | Minimum          
Reconciliation of contingent consideration obligations related to acquisitions          
Estimated undiscounted royalty amounts payable     $ 2,000,000    
MuGard | Maximum          
Reconciliation of contingent consideration obligations related to acquisitions          
Estimated undiscounted royalty amounts payable     $ 6,000,000