CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
U.S. product sales, net	$ 432,170	$ 341,816	$ 109,998
Service revenues, net	99,604	24,132	0
License fee, collaboration and other revenues	317	52,328	14,386
Total revenues	532,091	418,276	124,384
Costs and expenses:
Cost of product sales (excluding impairment)	96,314	78,509	20,306
Cost of services	20,575	9,992	0
Research and development expenses	66,084	42,878	24,160
Selling, general and administrative expenses	249,870	160,309	72,254
Impairment of intangible assets	19,663	0	0
Acquisition-related costs	0	11,232	9,478
Restructuring expenses	715	4,136	2,023
Total costs and expenses	453,221	307,056	128,221
Operating income (loss)	78,870	111,220	(3,837)
Other income (expense):
Interest expense	(73,153)	(53,251)	(14,697)
Loss on debt extinguishment	0	(10,449)	0
Interest and dividend income	3,149	1,512	975
Other income (expense)	189	(9,188)	217
Total other income (expense)	(69,815)	(71,376)	(13,505)
Income (loss) before income taxes	9,055	39,844	(17,342)
Income tax expense (benefit)	11,538	7,065	(153,159)
Net income (loss)	$ (2,483)	$ 32,779	$ 135,817
Net income (loss) per share:
Basic (USD per share)	$ (0.07)	$ 1.04	$ 6.06
Diluted (USD per share)	$ (0.07)	$ 0.93	$ 5.45
Weighted average shares outstanding used to compute net income (loss) per share:
Basic (shares)	34,346	31,471	22,416
Diluted (shares)	34,346	35,308	25,225