Equity-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Equity-based compensation expense
Total equity-based compensation expense	$ 5,468	$ 4,888	$ 16,809	$ 11,572
Income tax effect	(1,568)	(871)	(4,637)	(3,464)
After-tax effect of equity-based compensation expense	3,900	4,017	12,172	8,108
Cost of product sales
Equity-based compensation expense
Total equity-based compensation expense	118	159	395	254
Research and development
Equity-based compensation expense
Total equity-based compensation expense	858	1,028	2,583	2,071
Selling, general and administrative
Equity-based compensation expense
Total equity-based compensation expense	$ 4,492	$ 3,701	$ 13,831	$ 9,247