Equity-Based Compensation - Activity Related to Plans (Details)	9 Months Ended
	Sep. 30, 2016 shares
Stock Options
Stock Options
Outstanding at beginning of period (in shares)	2,904,177
Granted (in shares)	698,809
Exercised (in shares)	(86,584)
Expired or forfeited (in shares)	(325,720)
Outstanding at end of period (in shares)	3,190,682
Stock Options | 2007 Equity Plan
Stock Options
Outstanding at beginning of period (in shares)	1,963,162
Granted (in shares)	532,659
Exercised (in shares)	(86,584)
Expired or forfeited (in shares)	(191,938)
Outstanding at end of period (in shares)	2,217,299
Stock Options | 2000 Equity Plan
Stock Options
Outstanding at beginning of period (in shares)	14,040
Granted (in shares)	0
Exercised (in shares)	0
Expired or forfeited (in shares)	0
Outstanding at end of period (in shares)	14,040
Stock Options | 2013 Lumara Equity Plan
Stock Options
Outstanding at beginning of period (in shares)	96,000
Granted (in shares)	56,150
Exercised (in shares)	0
Expired or forfeited (in shares)	(47,532)
Outstanding at end of period (in shares)	104,618
Stock Options | Inducement Grants
Stock Options
Outstanding at beginning of period (in shares)	830,975
Granted (in shares)	110,000
Exercised (in shares)	0
Expired or forfeited (in shares)	(86,250)
Outstanding at end of period (in shares)	854,725
Restricted Stock Units
Restricted Stock Units
Outstanding at beginning of year (in shares)	654,355
Granted (in shares)	716,726
Vested (in shares)	(270,288)
Forfeited (in shares)	(102,914)
Outstanding at end of year (in shares)	997,879
Restricted Stock Units | 2007 Equity Plan
Restricted Stock Units
Outstanding at beginning of year (in shares)	446,330
Granted (in shares)	652,226
Vested (in shares)	(194,970)
Forfeited (in shares)	(88,424)
Outstanding at end of year (in shares)	815,162
Restricted Stock Units | 2000 Equity Plan
Restricted Stock Units
Outstanding at beginning of year (in shares)	0
Granted (in shares)	0
Vested (in shares)	0
Forfeited (in shares)	0
Outstanding at end of year (in shares)	0
Restricted Stock Units | 2013 Lumara Equity Plan
Restricted Stock Units
Outstanding at beginning of year (in shares)	52,350
Granted (in shares)	0
Vested (in shares)	(16,749)
Forfeited (in shares)	(8,990)
Outstanding at end of year (in shares)	26,611
Restricted Stock Units | Inducement Grants
Restricted Stock Units
Outstanding at beginning of year (in shares)	155,675
Granted (in shares)	64,500
Vested (in shares)	(58,569)
Forfeited (in shares)	(5,500)
Outstanding at end of year (in shares)	156,106