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Fair Value Measurements - Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($)
Sep. 30, 2016
Dec. 31, 2015
Fair value of assets and liabilities measured on a recurring basis    
Transfers or reclassifications of securities from Level 1 to Level 2 $ 0  
Transfers or reclassifications of securities from Level 2 to Level 1 0  
Fair Value, Measurements, Recurring    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 314,481,000 $ 311,302,000
Total liabilities 227,453,000 222,559,000
Fair Value, Measurements, Recurring | Contingent consideration | Lumara Health    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 225,137,000 214,895,000
Fair Value, Measurements, Recurring | Contingent consideration | MuGard    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 2,316,000 7,664,000
Fair Value, Measurements, Recurring | Cash equivalents    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 5,689,000 73,676,000
Fair Value, Measurements, Recurring | Corporate debt securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 252,694,000 200,677,000
Fair Value, Measurements, Recurring | U.S. treasury and government agency securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 9,947,000  
Fair Value, Measurements, Recurring | Commercial paper    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 31,852,000 34,449,000
Fair Value, Measurements, Recurring | Certificates of deposit    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 11,800,000  
Fair Value, Measurements, Recurring | Municipal securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 2,499,000 2,500,000
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 5,689,000 73,676,000
Total liabilities 0 0
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent consideration | Lumara Health    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 0 0
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent consideration | MuGard    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 0 0
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Cash equivalents    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 5,689,000 73,676,000
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Corporate debt securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | U.S. treasury and government agency securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0  
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Commercial paper    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Certificates of deposit    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0  
Fair Value, Measurements, Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Municipal securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2)    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 308,792,000 237,626,000
Total liabilities 0 0
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Contingent consideration | Lumara Health    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 0 0
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Contingent consideration | MuGard    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 0 0
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Cash equivalents    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Corporate debt securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 252,694,000 200,677,000
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | U.S. treasury and government agency securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 9,947,000  
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Commercial paper    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 31,852,000 34,449,000
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Certificates of deposit    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 11,800,000  
Fair Value, Measurements, Recurring | Significant Other Observable Inputs (Level 2) | Municipal securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 2,499,000 2,500,000
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3)    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Total liabilities 227,453,000 222,559,000
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Contingent consideration | Lumara Health    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 225,137,000 214,895,000
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Contingent consideration | MuGard    
Fair value of assets and liabilities measured on a recurring basis    
Total liabilities 2,316,000 7,664,000
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Cash equivalents    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Corporate debt securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | U.S. treasury and government agency securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0  
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Commercial paper    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0 0
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Certificates of deposit    
Fair value of assets and liabilities measured on a recurring basis    
Total assets 0  
Fair Value, Measurements, Recurring | Significant Unobservable Inputs (Level 3) | Municipal securities    
Fair value of assets and liabilities measured on a recurring basis    
Total assets $ 0 $ 0