CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
U.S. product sales, net	$ 115,777	$ 88,917	$ 308,324	$ 250,984
Service revenues, net	27,965	7,177	71,863	7,177
License fee, collaboration and other revenues	40	58	313	51,380
Total revenues	143,782	96,152	380,500	309,541
Costs and expenses:
Cost of product sales	25,706	19,088	65,942	59,793
Cost of services	4,984	3,261	15,705	3,261
Research and development expenses	17,116	19,809	45,579	34,981
Selling, general and administrative expenses	57,216	46,141	172,314	110,054
Impairment charges of intangible assets	0	0	15,963	0
Acquisition-related costs	0	8,500	0	11,153
Restructuring expenses	0	738	712	1,752
Total costs and expenses	105,022	97,537	316,215	220,994
Operating income (loss)	38,760	(1,385)	64,285	88,547
Other income (expense):
Interest expense	(18,309)	(14,222)	(55,002)	(34,794)
Loss on debt extinguishment	0	(10,449)	0	(10,449)
Interest and dividend income	838	524	2,319	967
Other income (expense)	(24)	(9,182)	197	(9,180)
Total other income (expense)	(17,495)	(33,329)	(52,486)	(53,456)
Income (loss) before income taxes	21,265	(34,714)	11,799	35,091
Income tax expense (benefit)	5,069	(14,130)	3,725	9,513
Net income (loss)	$ 16,196	$ (20,584)	$ 8,074	$ 25,578
Net income (loss) per share:
Basic (in usd per share)	$ 0.47	$ (0.62)	$ 0.23	$ 0.84
Diluted (in usd per share)	$ 0.43	$ (0.62)	$ 0.23	$ 0.73
Weighted average shares outstanding used to compute net income (loss) per share:
Basic (in shares)	34,171	33,223	34,377	30,379
Diluted (in shares)	42,111	33,223	34,764	34,962