Equity-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2016

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of details regarding stock options granted under equity incentive plans

The following table summarizes stock option activity for the nine months ended September 30, 2016:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2015	1,963,162		14,040	96,000		830,975		2,904,177
Granted	532,659		—	56,150		110,000		698,809
Exercised	(86,584	)	—	—		—		(86,584	)
Expired or terminated	(191,938	)	—	(47,532	)	(86,250	)	(325,720	)
Outstanding at September 30, 2016	2,217,299		14,040	104,618		854,725		3,190,682

Summary of details regarding restricted stock units granted under equity incentive plans

The following table summarizes RSU activity for the nine months ended September 30, 2016:

	2007 Equity		2000 Equity	2013 Lumara		Inducement
	Plan		Plan	Equity Plan		Grants		Total
Outstanding at December 31, 2015	446,330		—	52,350		155,675		654,355
Granted	652,226		—	—		64,500		716,726
Vested	(194,970	)	—	(16,749	)	(58,569	)	(270,288	)
Expired or terminated	(88,424	)	—	(8,990	)	(5,500	)	(102,914	)
Outstanding at September 30, 2016	815,162		—	26,611		156,106		997,879

Schedule of equity-based compensation expense

Equity-based compensation expense for the three and nine months ended September 30, 2016 and 2015 consisted of the following (in thousands):

	Three Months Ended September 30,						Nine Months Ended September 30,
	2016			2015			2016			2015
Cost of product sales	$	118		$	159		$	395		$	254
Research and development	858			1,028			2,583			2,071
Selling, general and administrative	4,492			3,701			13,831			9,247
Total equity-based compensation expense	$	5,468		$	4,888		$	16,809		$	11,572
Income tax effect	(1,568		)	(871		)	(4,637		)	(3,464		)
After-tax effect of equity-based compensation expense	$	3,900		$	4,017		$	12,172		$	8,108