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Recognition of Share-Based Compensation Expense (Detail) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Share based Compensation Arrangement by Share-based Payment Award [Line Items]        
Research and development $ 1,281 $ 805 $ 2,719 $ 2,831
Share based Compensation Expense recognized in Operations 289 315 487 630
Stock options
       
Share based Compensation Arrangement by Share-based Payment Award [Line Items]        
Research and development 56 81 113 162
General and administrative 141 234 282 468
Share based Compensation Expense recognized in Operations 197 315 395 630
Restricted Stock Units (RSUs)
       
Share based Compensation Arrangement by Share-based Payment Award [Line Items]        
General and administrative $ 92 $ 0 $ 92 $ 0