Tax Matters - Reconciliation of Gross Unrecognized Tax Benefits (Details) - USD ($) $ in Millions		12 Months Ended
		Dec. 31, 2021		Dec. 31, 2020		Dec. 31, 2019
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Balance, beginning		$ (5,595)	[1]	$ (5,381)	[1]	$ (6,259)
Acquisitions		0		37		(44)
Divestitures	[2]	0		265		0
Increases based on tax positions taken during a prior period	[3]	(111)		(232)		(36)
Decreases based on tax positions taken during a prior period	[3],[4]	103		64		1,109
Decreases based on settlements for a prior period	[5]	24		15		100
Increases based on tax positions taken during the current period	[3]	(550)		(411)		(383)
Impact of foreign exchange		22		(72)		25
Other, net	[3],[6]	40		120		107
Balance, ending	[1]	$ (6,068)		$ (5,595)		$ (5,381)

[1] In 2021, included in Income taxes payable ($19 million), Other current assets ($42 million) Noncurrent deferred tax assets and other noncurrent tax assets ($3.0 billion), Noncurrent deferred tax liabilities ($5 million) and Other taxes payable ($3.0 billion). In 2020, included in Income taxes payable ($34 million), Noncurrent deferred tax assets and other noncurrent tax assets ($18 million), Noncurrent deferred tax liabilities ($3.0 billion) and Other taxes payable ($2.5 billion).

[2] For 2020, related to the separation of Upjohn. See Note 2B.

[3] Primarily included in Provision/(benefit) for taxes on income.

[4] Primarily related to effectively settling certain issues with the U.S. and foreign tax authorities. See Note 5A.

[5] Primarily related to cash payments and reductions of tax attributes.

[6] Primarily related to decreases as a result of a lapse of applicable statutes of limitations.