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Acquisitions, Assets and Liabilities Held for Sale, Licensing Agreements, Research and Development and Collaborative Arrangements, Equity-Method Investments and Cost-Method Investment - Research and Development and Collaborative Arrangements (Detail) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Oct. 31, 2013
Dec. 31, 2016
May 31, 2016
Apr. 30, 2016
Jan. 31, 2016
Mar. 31, 2015
Feb. 28, 2015
Dec. 31, 2014
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenues from collaborative arrangements [1]                 $ 52,824,000,000 $ 48,851,000,000 $ 49,605,000,000
Cost of sales [1],[2]                 (12,329,000,000) (9,648,000,000) (9,577,000,000)
Selling, informational and administrative expenses [1],[2]                 (14,837,000,000) (14,809,000,000) (14,097,000,000)
Research and development expenses [1],[2]                 (7,872,000,000) (7,690,000,000) (8,393,000,000)
Other income/(deductions)—net [1]                 (3,655,000,000) (2,860,000,000) (1,009,000,000)
NovaQuest Co-Investment Fund II, L.P. [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Amount refunded to NovaQuest   $ 31,300,000                  
Maximum funding amount     $ 250,000,000                
Percentage of costs to be reimbursed     40.00%                
Reduction to research and development expense                 180,300,000    
NovaQuest Co-Investment Fund V, L.P. [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Maximum funding amount       $ 200,000,000              
Percentage of costs to be reimbursed       100.00%              
Reduction to research and development expense                 46,600,000    
Research and development, contingent payments, maximum exposure       $ 267,000,000              
Period to pay royalties       8 years              
RPI Finance Trust [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Maximum funding amount         $ 300,000,000            
Percentage of costs to be reimbursed         100.00%            
Reduction to research and development expense                 44,900,000    
Research and development, contingent payments, maximum exposure         $ 250,000,000            
Period to pay royalties         7 years            
Collaborative Arrangement [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenues from collaborative arrangements                 2,405,000,000 1,956,000,000 1,743,000,000
Cost of sales [3]                 (315,000,000) (282,000,000) (280,000,000)
Selling, informational and administrative expenses [4]                 (5,000,000) (287,000,000) (268,000,000)
Research and development expenses [5]                 64,000,000 (330,000,000) (1,210,000,000)
Other income/(deductions)—net [6]                 542,000,000 482,000,000 518,000,000
Upfront payments and milestone payments                 15,000,000 310,000,000 1,200,000,000
Collaborative arrangement sales based milestones payments                   20,000,000 80,000,000
Collaborative Arrangement [Member] | Eli Lilly & Company [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Proceeds received from upfront payments and milestone payments                 120,000,000    
Collaborative Arrangement [Member] | OPKO Health, Inc. [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront payments and milestone payments             $ 295,000,000        
Potential milestone payments             $ 275,000,000        
Collaborative Arrangement [Member] | Merck KGaA [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Potential milestone payments                 2,000,000,000    
Collaborative Arrangement [Member] | Merck KGaA [Member] | Research and Development Expense [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront payments and milestone payments                     1,200,000,000
Collaborative Arrangement [Member] | Deferred Revenue [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Proceeds received from upfront payments and milestone payments           $ 200,000,000          
Collaborative Arrangement [Member] | Deferred Revenue [Member] | Eli Lilly & Company [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Proceeds received from upfront payments and milestone payments           $ 200,000,000          
Collaborative Arrangement, Product [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenues—Revenues [7]                 659,000,000 644,000,000 786,000,000
Collaborative Arrangement, Co-promotion [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenues—Alliance revenues [8]                 $ 1,746,000,000 $ 1,312,000,000 957,000,000
Royalty revenue, term 36 months                    
Collaborative Arrangement, Co-promotion [Member] | Merck KGaA [Member] | Research and Development Expense [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront payments and milestone payments                     $ 309,000,000
Collaborative Arrangement, Upfront Cash Payment [Member] | Merck KGaA [Member] | Research and Development Expense [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront payments and milestone payments               $ 850,000,000      
[1] Amounts may not add due to rounding.
[2] Exclusive of amortization of intangible assets, except as disclosed in Note 1K. Basis of Presentation and Significant Accounting Policies: Amortization of Intangible Assets, Depreciation and Certain Long-Lived Assets.
[3] Primarily relates to royalties earned by our partners and cost of sales associated with inventory purchased from our partners.
[4] Represents net reimbursements to our partners for selling, informational and administrative expenses incurred.
[5] Primarily relates to upfront payments and pre-approval milestone payments earned by our partners as well as net reimbursements. The upfront and milestone payments were as follows: $15 million in 2016, $310 million in 2015 (primarily related to our collaboration with OPKO, see below) and $1.2 billion in 2014 (related to our collaboration with Merck KGaA, see below). 2016 also includes a $120 million reimbursement related to our collaboration with Lilly (see below).
[6] In 2016, 2015 and 2014, includes royalties earned on sales of Enbrel in the U.S. and Canada after October 31, 2013. On that date, the co-promotion term of the collaboration agreement for Enbrel in the U.S. and Canada expired, and we became entitled to royalties for a 36-month period thereafter until October 31, 2016.
[7] Represents sales to our partners of products manufactured by us.
[8] Substantially all relates to amounts earned from our partners under co-promotion agreements. The increase in 2016 reflects an increase in alliance revenues from Eliquis and the inclusion of Xtandi revenues resulting from the acquisition of Medivation in September 2016, partially offset by the expiration of the Rebif co-promotion collaboration at the end of 2015. The increase in 2015 reflects an increase in alliance revenues from Eliquis, partially offset by Spiriva (as a result of the expiration of the co-promotion collaboration in the U.S. and certain European countries during 2014).