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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001181431-06-005787.txt : 20060126
<SEC-HEADER>0001181431-06-005787.hdr.sgml : 20060126
<ACCEPTANCE-DATETIME>20060126145246
ACCESSION NUMBER:		0001181431-06-005787
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060117
FILED AS OF DATE:		20060126
DATE AS OF CHANGE:		20060126

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SIMON RONALD I
		CENTRAL INDEX KEY:			0001060435

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-14136
		FILM NUMBER:		06553244

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		212-355-4141

	MAIL ADDRESS:	
		STREET 1:		485 MADISON AVENUE
		STREET 2:		14TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cardium Therapeutics, Inc.
		CENTRAL INDEX KEY:			0000772320
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				840635673
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3611 VALLEY CENTRE DRIVE, SUITE 525
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(858) 436-1000

	MAIL ADDRESS:	
		STREET 1:		3611 VALLEY CENTRE DRIVE, SUITE 525
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Cadium Therapeutics, Inc.
		DATE OF NAME CHANGE:	20060118

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CARDIUM THERAPEUTICS, INC
		DATE OF NAME CHANGE:	20060118

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARIES VENTURES INC
		DATE OF NAME CHANGE:	20000523
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd105048.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-01-17</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000772320</issuerCik>
        <issuerName>Cardium Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>CDTP</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001060435</rptOwnerCik>
            <rptOwnerName>SIMON RONALD I</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3611 VALLEY CENTRE DRIVE, SUITE 525</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Non-Qualified Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.75</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2016-01-16</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The securities vest in equal monthly installments over a period of four years beginning on February 17, 2006.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Ronald I. Simon</signatureName>
        <signatureDate>2006-01-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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