-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001209191-09-051753.txt : 20091109
<SEC-HEADER>0001209191-09-051753.hdr.sgml : 20091109
<ACCEPTANCE-DATETIME>20091109185657
ACCESSION NUMBER:		0001209191-09-051753
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20091105
FILED AS OF DATE:		20091109
DATE AS OF CHANGE:		20091109

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SIMON NICHOLAS J III
		CENTRAL INDEX KEY:			0001221595

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-16614
		FILM NUMBER:		091169899

	MAIL ADDRESS:	
		STREET 1:		THE JOHN HANCOCK TOWER
		STREET 2:		200 CLARENDON STREET, 54TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PONIARD PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000755806
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				911261311
		STATE OF INCORPORATION:			WA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		7000 SHORELINE COURT
		STREET 2:		SUITE 270
		CITY:			SO. SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		2062862501

	MAIL ADDRESS:	
		STREET 1:		300 ELLIOTT AVENUE WEST
		STREET 2:		SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98119-4114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEORX CORP
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c92351_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-11-05</periodOfReport>

    <issuer>
        <issuerCik>0000755806</issuerCik>
        <issuerName>PONIARD PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>PARD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001221595</rptOwnerCik>
            <rptOwnerName>SIMON NICHOLAS J III</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MPM ASSET MANAGEMENT</rptOwnerStreet1>
            <rptOwnerStreet2>200 CLARENDON ST., 54TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02116</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-11-05</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>78262</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>8.0025</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6779949</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-11-06</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>264648</value>
                    <footnoteId id="F4"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>8.0581</value>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6515301</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-11-09</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>152052</value>
                    <footnoteId id="F7"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>8.50</value>
                    <footnoteId id="F8"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6363249</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F9"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The shares were sold as follows:  65,236 by MPM BioVentures III-QP, L.P. (&quot;BV III QP&quot;), 4,387 by MPM BioVentures III, L.P. (&quot;BV III&quot;), 1,155 by MPM Asset Management Investors 2005 BVIII LLC (&quot;AM 2005&quot;), 1,971 by MPM BioVentures III Parallel Fund, L.P. (&quot;BV Parallel&quot;) and 5,513 by MPM BioVentures III GmbH &amp; Co. Beteiligungs KG (&quot;BV KG&quot;).  MPM BioVentures III GP, L.P. and MPM BioVentures III LLC (&quot;BV III LLC&quot;) are the direct and indirect general partners of BV III QP, BV III , BV Parallel and BV KG.   The Reporting Person is a member of BV III LLC and AM 2005.</footnote>
        <footnote id="F2">The shares were sold at prices ranging from $8.00 to $8.0175.  The Reporting Person will provide, upon request to the SEC, the Issuer or securityholder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F3">The shares are held as follows: 5,651,531 by BV III QP, 380,015 by BV III, 100,106 by AM 2005, 170,718 by BV Parallel and 477,579 by BV KG.  The Reporting Person disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein.</footnote>
        <footnote id="F4">The shares were sold as follows:  220,601 by BV III QP, 14,833 by BV III, 3,908 by AM 2005, 6,664 by BV Parallel and 18,642 by BV KG.</footnote>
        <footnote id="F5">The shares were sold at prices ranging from $8.00 to $8.17.  The Reporting Person will provide upon request to the SEC, the Issuer or securityholder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F6">The shares are held as follows: 5,430,930 by BV III QP, 365,182 by BV III, 96,198 by AM 2005, 164,054 by BV Parallel and 458,937 by BV KG.  The Reporting Person disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein.</footnote>
        <footnote id="F7">The shares were sold as follows:  126,745 by BV III QP, 8,522 by BV III, 2,245 by AM 2005, 3,829 by BV Parallel and 10,711 by BV KG.</footnote>
        <footnote id="F8">The shares were sold at prices ranging from $8.50 to $8.51.  The Reporting Person will provide upon request to the SEC, the Issuer or securityholder of the Issuer, full information regarding the number of shares sold at each separate price.</footnote>
        <footnote id="F9">The shares are held as follows: 5,304,185 by BV III QP, 356,660 by BV III, 93,953 by AM 2005, 160,225 by BV Parallel and 448,226 by BV KG. The Reporting Person disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September
21, 2009.</remarks>

    <ownerSignature>
        <signatureName>/s/ Nicholas Simon III</signatureName>
        <signatureDate>2009-11-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----