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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 47CcAq9bmBHjA3BwZCstKw==

<SEC-DOCUMENT>0001179110-10-002256.txt : 20100208
<SEC-HEADER>0001179110-10-002256.hdr.sgml : 20100208
<ACCEPTANCE-DATETIME>20100208135409
ACCESSION NUMBER:		0001179110-10-002256
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100205
FILED AS OF DATE:		20100208
DATE AS OF CHANGE:		20100208

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PERRY MICHAEL S
		CENTRAL INDEX KEY:			0001250379

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-16614
		FILM NUMBER:		10580403

	MAIL ADDRESS:	
		STREET 1:		C/O BIOTRANSPLANT INC
		STREET 2:		196 BOSTON AVE SUITE 2800
		CITY:			MEDFORD
		STATE:			MA
		ZIP:			02155

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PONIARD PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000755806
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				911261311
		STATE OF INCORPORATION:			WA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		7000 SHORELINE COURT
		STREET 2:		SUITE 270
		CITY:			SO. SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		2062862501

	MAIL ADDRESS:	
		STREET 1:		300 ELLIOTT AVENUE WEST
		STREET 2:		SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98119-4114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEORX CORP
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 3 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-02-05</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000755806</issuerCik>
        <issuerName>PONIARD PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>PARD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001250379</rptOwnerCik>
            <rptOwnerName>PERRY MICHAEL S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7000 SHORELINE CT, SUITE 270</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>S SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94080</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CMO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Restricted Stock Units</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Dr. Perry was award 15,000 performance-based restricted stock units 12/08/2009 as a consultant of the Company.  Each unit represents a contingent right to receive one share of PARD common stock.  The units vest in two 50% segments based upon achievement of specific performance targets, subject to forfeiture or acceleration upon the occurrence of certain events described in the Unit Award Notice and Agreement.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Michael S. Perry</signatureName>
        <signatureDate>2010-02-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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