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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PBlohMEoWLN0klFMPCmEmGYHHG19q4JqRryS9HxhotIcdBTwOJmZdTGpLC5VUmik
 qGYH6t43pGs6EqdU/dXCcQ==

<SEC-DOCUMENT>0001179110-06-015567.txt : 20060725
<SEC-HEADER>0001179110-06-015567.hdr.sgml : 20060725
<ACCEPTANCE-DATETIME>20060725171003
ACCESSION NUMBER:		0001179110-06-015567
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060724
FILED AS OF DATE:		20060725
DATE AS OF CHANGE:		20060725

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PONIARD PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000755806
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				911261311
		STATE OF INCORPORATION:			WA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		300 ELLIOTT AVENUE WEST
		STREET 2:		SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98119-4114
		BUSINESS PHONE:		2062817001

	MAIL ADDRESS:	
		STREET 1:		300 ELLIOTT AVENUE WEST
		STREET 2:		SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98119-4114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEORX CORP
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Glassberg Alan B M.D.
		CENTRAL INDEX KEY:			0001307228

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-16614
		FILM NUMBER:		06979719

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		206-286-2501

	MAIL ADDRESS:	
		STREET 1:		300 ELLIOTT AVE. WEST
		STREET 2:		SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98119-4114
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 3 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-07-24</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000755806</issuerCik>
        <issuerName>PONIARD PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>PARD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001307228</rptOwnerCik>
            <rptOwnerName>Glassberg Alan B M.D.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>300 ELLIOTT AVE WEST</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 500</rptOwnerStreet2>
            <rptOwnerCity>SEATLE</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98119-4114</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Medical Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock option</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.49</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-10-20</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Poniard common stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>40000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>.67</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-06-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Poniard common stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>95000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The reporting person ceased to be subject to Section 16 as a director on 6/16/06.  The reporting person became a Section 16 officer on 7/24/06 and therefore is filing this Form 3.</footnote>
        <footnote id="F2">Exercisable in two equal annual installments immediately following the next two annual meetings.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/  Mike Jackson</signatureName>
        <signatureDate>2006-07-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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