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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 KHpsCgubjGwIkKI8zD0w++qpM6vHxc4mrDClXggKrFcSKKunbryRS0O4sfWFga5C
 7lfLFhnDrrBCNidvrvex0Q==

<SEC-DOCUMENT>0001209191-08-020136.txt : 20080325
<SEC-HEADER>0001209191-08-020136.hdr.sgml : 20080325
<ACCEPTANCE-DATETIME>20080325194555
ACCESSION NUMBER:		0001209191-08-020136
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080123
FILED AS OF DATE:		20080325
DATE AS OF CHANGE:		20080325

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Burns Daniel Joseph
		CENTRAL INDEX KEY:			0001425443

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-00935
		FILM NUMBER:		08710499

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		760-994-6660

	MAIL ADDRESS:	
		STREET 1:		POB 1086
		CITY:			DEL MAR
		STATE:			CA
		ZIP:			92014

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CytoCore Inc
		CENTRAL INDEX KEY:			0000075439
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				364296006
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		414 NORTH ORLEANS STREET
		STREET 2:		SUITE 502
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60610
		BUSINESS PHONE:		4078490290

	MAIL ADDRESS:	
		STREET 1:		414 NORTH ORLEANS STREET
		STREET 2:		SUITE 502
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60610

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MOLECULAR DIAGNOSTICS INC
		DATE OF NAME CHANGE:	20011009

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMPERSAND MEDICAL CORP
		DATE OF NAME CHANGE:	19990527

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BELL NATIONAL CORP
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c25160_01djb.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-01-23</periodOfReport>

    <issuer>
        <issuerCik>0000075439</issuerCik>
        <issuerName>CytoCore Inc</issuerName>
        <issuerTradingSymbol>CYOE.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001425443</rptOwnerCik>
            <rptOwnerName>Burns Daniel Joseph</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOCORE, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>414 N. ORLEANS ST, SUITE 502</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60610</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, $.001 par</value>
            </securityTitle>
            <transactionDate>
                <value>2008-01-23</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3200500</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares of restricted common stock granted in consideration for services rendered during 2007 fiscal year.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Daniel J. Burns</signatureName>
        <signatureDate>2008-03-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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