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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001209191-08-020018.txt : 20080325
<SEC-HEADER>0001209191-08-020018.hdr.sgml : 20080325
<ACCEPTANCE-DATETIME>20080325145114
ACCESSION NUMBER:		0001209191-08-020018
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080123
FILED AS OF DATE:		20080325
DATE AS OF CHANGE:		20080325

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MCCULLOGH ROBERT F JR
		CENTRAL INDEX KEY:			0001341597

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-00935
		FILM NUMBER:		08709161

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		415 398 0154

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 151
		CITY:			KENTFIELD
		STATE:			CA
		ZIP:			94914

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CytoCore Inc
		CENTRAL INDEX KEY:			0000075439
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				364296006
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		414 NORTH ORLEANS STREET
		STREET 2:		SUITE 502
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60610
		BUSINESS PHONE:		4078490290

	MAIL ADDRESS:	
		STREET 1:		414 NORTH ORLEANS STREET
		STREET 2:		SUITE 502
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60610

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MOLECULAR DIAGNOSTICS INC
		DATE OF NAME CHANGE:	20011009

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMPERSAND MEDICAL CORP
		DATE OF NAME CHANGE:	19990527

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BELL NATIONAL CORP
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c25160_01rfm.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-01-23</periodOfReport>

    <issuer>
        <issuerCik>0000075439</issuerCik>
        <issuerName>CytoCore Inc</issuerName>
        <issuerTradingSymbol>CYOE.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001341597</rptOwnerCik>
            <rptOwnerName>MCCULLOGH ROBERT F JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOCORE, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>414 N. ORLEANS ST, SUITE 502</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60610</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>CEO and CFO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, $.001 par</value>
            </securityTitle>
            <transactionDate>
                <value>2008-01-23</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>347417</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $.001 par</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>410750</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $.001 par</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>158705</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares of restricted common stock granted in consideration for services rendered during 2007 fiscal year.</footnote>
        <footnote id="F2">Shares owned by Summitcrest Capital, LP, of which the Reporting Person is the President of the General Partner.</footnote>
        <footnote id="F3">Shares owned by the MJM Educational Trust (12,500 shares), PFM Educational Trust (12,500 shares), CDM Educational Trust (12,500 shares) and the MPC Trust (121,205 shares), of which trusts the Reporting Person is a trustee.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Robert F. McCullough, Jr.</signatureName>
        <signatureDate>2008-03-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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