8-K

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934



Date of Report (Date of earliest event reported)            May 10, 2006
                                                --------------------------------


                           Molecular Diagnostics, Inc.
               (Exact name of registrant as specified in charter)

       Delaware                         0-935                  36-4296006
- --------------------------------------------------------------------------------
(State or other jurisdiction        (Commission               (IRS Employer
of incorporation)                   File Number)             Identification No.)


414 North Orleans Street, Suite 502, Chicago, Illinois                 60610
- --------------------------------------------------------------------------------
       (Address of principal executive offices)                     (Zip Code)


Registrant's telephone number, including area code          (312) 222-9550
                                                   -----------------------------

                                 NotApplicable
- --------------------------------------------------------------------------------
         (Former name or former address, if changed since last report.)



      Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

|_|   Written communications pursuant to Rule 425 under the Securities Act (17
      CFR 230.425)

|_|   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12)

|_|   Pre-commencement communications pursuant to Rule 14d-2(b) under the
      Exchange Act (17 CFR 240.14d-2(b))

|_|   Pre-commencement communications pursuant to Rule 13e-4(c) under the
      Exchange Act (17 CFR 240.13e-4(c))







ITEM 4.01. CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT

      (a) Previous independent registered public accounting firm

            (i) On May 10, 2006, Registrant was informed by Altschuler,  Melvoin
and  Glasser  LLP that  such  firm was  resigning  as  Registrant's  independent
registered public accounting firm.

            (ii) The  report  of  Altschuler,  Melvoin  and  Glasser  LLP on the
consolidated  financial  statements for fiscal 2005 contained no adverse opinion
or disclaimer  of opinion and was not  qualified or modified as to  uncertainty,
audit scope or accounting principles, except that the opinion contained a "going
concern" explanatory  paragraph.  The report of Altschuler,  Melvoin and Glasser
LLP on the  consolidated  financial  statements  for fiscal  2004  contained  no
adverse opinion or disclaimer of opinion and was not qualified or modified as to
uncertainty,  audit  scope or  accounting  principles,  except  that the opinion
contained a "going concern" explanatory paragraph and a disclaimer of opinion on
the  financial  statements  for the  year  ended  December  31,  2003  of  Samba
Technologies,   SARL,  a  wholly-owned  subsidiary  of  the  Registrant,   which
statements were audited by other auditors.

            (iii) In  connection  with its audits for the two most recent fiscal
years  and  through  May  10,  2006,  there  have  been  no  disagreements  with
Altschuler,  Melvoin and Glasser LLP on any matter of  accounting  principles or
practices, financial statement disclosure, or auditing scope or procedure, which
disagreements  if not resolved to the  satisfaction  of Altschuler,  Melvoin and
Glasser LLP would have caused them to make reference  thereto in their report on
the financial statements for such years.

            (iv) The  Registrant  has  requested  that  Altschuler,  Melvoin and
Glasser LLP furnish it with a letter addressed to the SEC stating whether or not
it agrees with the above statements.  A copy of such letter,  dated May 15, 2006
is filed as Exhibit 16 to this Form 8-K.

      (b) New independent registered public accounting firm

      On May 15, 2006, the Registrant engaged Amper,  Politziner & Mattia,  P.C.
to act as its registered  public  accounting firm.  Amper,  Politziner & Mattia,
P.C.  replaces  Altschuler,  Melvoin and Glasser LLP, which firm resigned on May
10, 2006.

      Prior to the engagement of Amper,  Politziner & Mattia,  P.C., neither the
Registrant  nor  anyone  on  behalf  of the  Registrant  consulted  with  Amper,
Politziner & Mattia,  P.C. during the  Registrant's two most recent fiscal years
and  through May 15,  2006,  on any manner  regarding:  (A) the  application  of
accounting  principles to a specific completed or contemplated  transaction,  or
the type of audit opinion that might be rendered on the  Registrant's  financial
statements  or  either  written  or oral  advice  that was an  important  factor
considered  by the  Registrant  in  reaching  a decision  as to the  accounting,
auditing  or  financial  reporting  issue,  or  (B)  the  subject  of  either  a
disagreement or event specified in Item 304(a)(1)(iv) of Regulation S-B.

ITEM 9.01.  FINANCIAL STATEMENTS AND EXHIBITS

      (d) Exhibits: The following exhibit is filed with this report:

Exhibit 16        Letter from Altschuler, Melvoin and Glasser LLP






                                   SIGNATURES

      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                            Molecular Diagnostics, Inc.


Dated: May 16, 2006                         By:/s/ David Weissberg, M.D.
                                            ----------------------------
                                            David Weissberg, M.D.
                                            Chairman and Chief Executive Officer

EX-16