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Note 5 - Acquisition of EGEN, Inc. (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended 12 Months Ended 25 Months Ended
Jun. 16, 2017
Jun. 10, 2014
Jun. 09, 2014
Jun. 20, 2014
Nov. 30, 2013
Sep. 30, 2017
Dec. 31, 2016
Jun. 10, 2014
Sep. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Jun. 20, 2016
Jun. 30, 2017
Gain (Loss) from Change in Fair Value of Earn out Milestone Liability           $ 1,200,000       $ 649,701 $ 733,186    
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)                   $ 2,520,000 1,444,023    
Finite-Lived Intangible Asset, Useful Life                   10 years      
Amortization of Intangible Assets                   5,625    
Finite-Lived Intangible Assets, Net             $ 1,022,924     795,608 1,022,924    
Finite-Lived Intangible Assets, Accumulated Amortization             7,500     7,500 7,500    
Noncompete Agreements [Member]                          
Amortization of Intangible Assets             568,290     277,316      
Finite-Lived Intangible Assets, Net             1,022,924     795,608 1,022,924    
Finite-Lived Intangible Assets, Accumulated Amortization             568,290     795,606 $ 568,290    
Indefinite-lived in Process Research and Development [Member]                          
Gain (Loss) from Change in Fair Value of Earn out Milestone Liability             (700,000)            
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)             1,400,000            
Hercules [Member] | Hercules Credit Agreement [Member]                          
Proceeds from Lines of Credit     $ 5,000,000   $ 5,000,000     $ 10,000,000          
EGEN Inc [Member]                          
Business Combination, Consideration Transferred                       $ 27,600,000  
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High       $ 30,400,000           24,400,000      
Payments to Acquire Businesses, Gross       $ 3,000,000                  
Stock Issued During Period, Shares, Acquisitions       193,728                  
Business Acquisition, Equity Interest Issued or Issuable, Number of Shares 47,862                        
Gain (Loss) from Change in Fair Value of Earn out Milestone Liability                   600,000      
Goodwill, Acquired During Period       $ 2,000,000                  
EGEN Inc [Member] | Noncompete Agreements [Member]                          
Finite-lived Intangible Assets Acquired             $ 1,600,000            
Finite-Lived Intangible Asset, Useful Life             7 years            
EGEN Inc [Member] | Indefinite-lived in Process Research and Development [Member]                          
Indefinite-lived Intangible Assets Acquired       24,200,000   6,900,000     $ 9,400,000        
Asset Impairment Charges           2,500,000              
Business Combination, Contingent Consideration, Liability           12,500,000     $ 12,500,000       $ 13,800,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)           $ 1,400,000 $ 700,000            
EGEN Inc [Member] | Hercules Credit Agreement [Member]                          
Payments to Acquire Businesses, Gross   $ 3,000,000                      
EGEN Inc [Member] | Ovarian Cancer Study Milestone [Member]                          
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High                   12,400,000      
EGEN Inc [Member] | Glioblastoma Multiforme Brain Cancer Study Milestone [Member]                          
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High                   $ 12,000,000      
EGEN Inc [Member] | Maximum [Member]                          
Business Combination, Consideration Transferred       $ 44,400,000