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Note 13 - Warrants (Tables)
 12 Months Ended
Dec. 31, 2016
Notes Tables  
Schedule of Warrant Activity [Table Text Block]
Warrants
 
Number of
Warrants
Issued
 
 
Weighted
Average
Exercise
Price
 
Warrants outstanding at January 1, 2015
    
5,069,815
 
   $
8.18
  
Warrants issued in connection with the May 2015 equity transaction
    
1,950,000
 
   $
2.60
  
Warrants expired during 2015
    
(1,125,140
)
   $
7.98
  
Warrants outstanding at December 31, 2015
    
5,894,675
 
   $
6.37
  
Warrants issued in connection with the 2016 equity transactions
    
16,066,371
 
   $
0.92
  
Warrants exercised during 2016
   
(250,000
)
   $
0.01
  
Warrants expired during 2016
    
(879,163
)
   $
14.94
  
Warrants outstanding at December 31, 2016
    
20,831,883
 
   $
1.88
  
                 
Aggregate intrinsic value of outstanding warrants at December 31, 2016
   $
534,000
 
    
 
  
                 
Weighted average remaining contractual terms (years)
    
3.32
 (1)