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Note 12 - Earn-out Milestone Liability (Tables)
12 Months Ended
Dec. 31, 2016
Notes Tables  
Schedule of Changes in Earn out Milestone Liabilities [Table Text Block]
Balance at January 1, 2015
  $
13,663,710
 
Non-cash loss from the adjustment for the change in fair value included in 2015 net loss
   
257,702
 
Balance at December 31, 2015
  $
13,921,412
 
Non-cash gain from the adjustment for the change in fair value included in 2016 net loss
   
(733,186
)
Balance at December 31, 2016
  $
13,188,226