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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2022
Stock-Based Compensation [Abstract]  
Weighted-Average Assumptions Used for Grants Issued The following weighted-average assumptions were used for stock options granted during the years ended December 31, 2022 and 2021:

    Year ended December 31,  
   
2022
    2021  
Weighted average risk-free rate
   
2.52
%
    1.09 %
Weighted average volatility
   
90.49
%
    134.64 %
Dividend yield
   
0
%
    0 %
Expected term
  5.79 years     6.10 years
 
Summarizes of Stock Option Activity

The following table summarizes stock option activity for the years ended December 31, 2022 and 2021 (in thousands except for per-share and remaining contractual life data):

   
Outstanding
Options
   
Weighted
Average
Exercise
Price per
Share
   
Weighted
Average
Remaining
Contractual
Life (in
years)
   
Aggregate
Intrinsic
Value
 
Outstanding January 1, 2021
   
-
   
$
-
      -    
$
-
 
Granted
   
199
     
168.04
                 
Cancelled
    -       -                  
Outstanding December 31, 2021
   
199
   
$
168.04
     
9.38
   
$
-
 
Granted
    287       17.29                  
Cancelled
    (127 )     140.56                  
Outstanding December 31, 2022     359     $ 57.18       7.57     $
-  
                                 
Options vested and exercisable at December 31, 2022
   
146
   
$
109.60
     
4.79
   
$
-
 
Summarizes of RSU Activity

The following table summarizes RSU activity for the years ended December 31, 2022 and 2021 (in thousands except for per-share data):

   
Outstanding
Restricted
Stock Units
   
Weighted
Average
Fair
Value per
Share
 
January 1, 2021
   
-
   
$
-
 
Granted
   
12
     
276.00
 
December 31, 2021
   
12
   

276.00
 
Granted
    55       38.60  
Released
    (3 )     271.42  
Cancelled
    (60 )     61.03  
December 31, 2022     4     $ 236.36  
                 
Balance expected to vest at December 31, 2022
   
4
         
RSUs Vested and Settled The following table shows the number of RSUs that vested and were settled during the year ended December 31, 2022, as well as the number of shares of common stock withheld to cover the withholding taxes and the net shares issued upon settlement (in thousands):



   
Year ended
 
   
December 31, 2022
 
RSUs vested
   
3
 
Common stock withheld to cover taxes
   
(1
)
Common stock issued
   
2
 
Stock-Based Compensation Expense

For the years ended December 31, 2022 and 2021, the Company recognized stock-based compensation expense as follows (in thousands):



   
Years ended December 31,
 
     
2022
     
2021
 
Research and development
  $
1,249
    $
1,597
 
General and administrative
   
1,686
     
3,638
 
Total
  $
2,935
    $
5,235