SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  FORM 12B-25

                        Commission File Number: 002-90539


                          NOTIFICATION OF LATE FILING

 [x]10-K         [ ]Form 11-K       [ ]Form 20-F         [ ]Form 10-Q
 [ ]Form N-SAR

     For Period Ended: September 30, 2005

 [ ]Transition Report on Form 10-K         [ ]Transition Report on Form 10-Q
 [ ]Transition Report on Form 20-F         [ ]Transition Report on Form N-SAR

     For the Transition Period Ended: _______________________________________

     Nothing  in  this  form shall be construed to imply that the Commission has
verified any information contained herein.

     If  the  notification  relates  to  a  portion of the filing checked above,
identify the item(s) to which the notification relates:_________________________
________________________________________________________________________________


                                     PART I
                             REGISTRANT INFORMATION

Full name of registrant                   Applied DNA Sciences, Inc.
Former name if applicable
Address of principal executive office     25 Health Sciences Drive, Suite 113
City, state and zip code                  Stony Brook, New York 11790

                                    PART II
                            RULE 12B-25 (B) AND (C)

     If  the  subject  report  could not be filed without unreasonable effort or
expense  and  the  registrant  seeks  relief  pursuant  to  Rule 12b-25 (b), the
following should be completed. (Check box if appropriate.)



   | (a)  The  reasons  described  in  reasonable  detail  in  Part  III of this
   |      form could not be eliminated without unreasonable effort or expense;
   | (b)  The  subject  annual  report,  semi-annual  report,  transition report
   |      on  Form  10-K,  20-F,  11-K  or Form 10-Q, or portion thereof will be
[x]|      filed  on or before the 15th calendar day following the prescribed due
   |      date;  or  the  subject  quarterly report or transition report on Form
   |      10-Q, or portion thereof will be filed on or before the fifth calendar
   |      day following the prescribed due date; and
   | (c)  The  accountant's  statement  or  other  exhibit  required  by  Rule
   |      12b-25(c) has been attached if applicable.




                                    PART III
                                    NARRATIVE

     State  below  in  reasonable  detail the reasons why Form 10-K, 11-K, 20-F,
10-Q,  N-SAR  or the transition report portion thereof could not be filed within
the prescribed time period.

     The compilation, dissemination and review of the information required to be
presented  in  the  Form  10-KSB  for  the relevant fiscal year has imposed time
constraints  that  have  rendered timely filing of the Form 10-KSB impracticable
without  undue hardship and expense to the registrant. The registrant undertakes
the  responsibility  to file such annual report no later than fifteen days after
its original due date.

                                    PART IV
                                OTHER INFORMATION

(1)  Name  and  telephone  number  of  person  to  contact  in  regard  to  this
notification

        James A. Hayward         (631)                444-6861
        ----------------      --------------       ----------------
        (Name)                 (Area Code)         (Telephone Number)

(2)  Have  all  other  periodic  reports  required  under Section 13 or 15(d) of
     the Securities Exchange Act of 1934 or Section 30 of the Investment Company
     Act  of 1940 during the preceding 12 months or for such shorter period that
     the  registrant  was  required  to  file  such report(s) been filed? If the
     answer is no, identify report(s).

                              [x] Yes  [ ]  No

(3)  Is  it  anticipated  that  any  significant change in results of operations
     from the corresponding period for the last fiscal year will be reflected by
     the  earnings  statements  to  be included in the subject report or portion
     thereof?

                              [ ] Yes  [x]  No

If  so:  attach  an  explanation of the anticipated change, both narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.




                           Applied DNA Sciences, Inc.
                  Name of Registrant as Specified in Charter.

Has  caused  this  notification  to  be  signed on its behalf by the undersigned
thereunto duly authorized.

Dated:  December 30, 2005                    /s/ JAMES A. HAYWARD
                                             --------------------
                                             By: James A. Hayward
                                             Title:  Chief Executive Officer