CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income	Accumulated Deficit	Total
Balance, beginning at Dec. 31, 2020	$ 40	$ 1,279,824	$ 2,589	$ (1,073,096)	$ 209,357
Balance, beginning (in shares) at Dec. 31, 2020	39,603,771
Increase (Decrease) in Stockholders' Equity
Shares issued under stock option and employee stock purchase plans		2,479			2,479
Shares issued under stock option and employee stock purchase plans (in shares)	281,189
Shares issued in underwritten offering, net	$ 7	269,886			269,893
Shares issued in underwritten offering, net (in shares)	6,845,238
Stock-based compensation		8,953			8,953
Unrealized gain (loss) on marketable securities			(695)		(695)
Net loss				(70,511)	(70,511)
Balance, ending at Dec. 31, 2021	$ 47	1,561,142	1,894	(1,143,607)	419,476
Balance, ending (in shares) at Dec. 31, 2021	46,730,198
Increase (Decrease) in Stockholders' Equity
Shares issued under stock option and employee stock purchase plans		4,076			4,076
Shares issued under stock option and employee stock purchase plans (in shares)	470,497
Stock-based compensation		15,611			15,611
Unrealized gain (loss) on marketable securities			(634)		(634)
Net loss				(112,325)	(112,325)
Balance, ending at Dec. 31, 2022	$ 47	1,580,829	1,260	(1,255,932)	$ 326,204
Balance, ending (in shares) at Dec. 31, 2022	47,200,695				47,200,695
Increase (Decrease) in Stockholders' Equity
Shares issued under stock option and employee stock purchase plans		2,236			$ 2,236
Shares issued under stock option and employee stock purchase plans (in shares)	143,932
Shares issued in underwritten offering, net	$ 9	216,213			216,222
Shares issued in underwritten offering, net (in shares)	8,538,750
Stock-based compensation		23,890			23,890
Unrealized gain (loss) on marketable securities			2,048		2,048
Net loss				(141,429)	(141,429)
Balance, ending at Dec. 31, 2023	$ 56	$ 1,823,168	$ 3,308	$ (1,397,361)	$ 429,171
Balance, ending (in shares) at Dec. 31, 2023	55,883,377				55,883,377