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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities:    
Net loss $ (29,361) $ (23,050)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 726 811
Amortization and premium of marketable securities, net (1,256) 772
Gain on fair value remeasurement of contingent consideration 0 (536)
Stock-based compensation expense 4,340 3,153
Changes in operating assets and liabilities:    
Accounts and other receivables (967) (71)
Prepaid and other current assets 2,722 (7,148)
Accounts payable and accrued expenses (3,448) (2,738)
Other liabilities (1,325) 4,273
Net cash used in operating activities (28,569) (24,534)
Cash flows from investing activities:    
Sales and maturities of marketable securities 127,000 27,845
Purchases of marketable securities (73,846) (16,890)
Acquisition of property and equipment (585) (575)
Net cash provided by investing activities 52,569 10,380
Cash flows from financing activities:    
Proceeds from issuance of stock from employee benefit plans 694 304
Net cash provided by financing activities 694 304
Net increase (decrease) in cash and cash equivalents 24,694 (13,850)
Cash and cash equivalents at beginning of period 29,429 39,143
Cash and cash equivalents at end of period 54,123 25,293
Non-cash investing activities    
Accrued construction in progress $ 134 $ 53