Nature of Business and Overview (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Nature of Business and Overview
Cash, cash equivalents and marketable securities	$ 305,000
Net loss	(112,325)	$ (70,511)	$ (59,780)
Net cash used in operations	$ (103,732)	$ (60,909)	$ (40,404)