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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities:    
Net loss $ (23,050) $ (16,538)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 811 775
Amortization and premium of marketable securities, net 772 (48)
Gain on sale or disposal of assets   (24)
(Gain) loss on fair value remeasurement of contingent consideration (536) 483
Stock-based compensation expense 3,153 1,275
Changes in operating assets and liabilities:    
Accounts and other receivables (71) (26)
Prepaid and other current assets (7,148) (2,137)
Accounts payable and accrued expenses (2,738) (1,266)
Other liabilities 4,273 (578)
Net cash used in operating activities (24,534) (18,084)
Cash flows from investing activities:    
Sales and maturities of marketable securities 27,845 78,000
Purchases of marketable securities (16,890) (33,970)
Acquisition of property and equipment (575) (567)
Proceeds from sale or disposal of assets   24
Net cash provided by investing activities 10,380 43,487
Cash flows from financing activities:    
Proceeds from issuance of stock from employee benefit plans 304 74
Net cash provided by financing activities 304 74
Net (decrease) increase in cash and cash equivalents (13,850) 25,477
Cash and cash equivalents at beginning of period 39,143 43,836
Cash and cash equivalents at end of period 25,293 $ 69,313
Non-cash investing activities    
Accrued construction in progress $ 53