Property and Equipment, Net (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Property and Equipment
Total property and equipment	$ 24,677	$ 25,052
Less: accumulated depreciation and amortization	(21,126)	(21,237)
Property and equipment, net	3,551	3,815
Depreciation and amortization expense	3,068	3,929	$ 4,858
Laboratory equipment
Property and Equipment
Total property and equipment	8,581	8,566
Manufacturing equipment
Property and Equipment
Total property and equipment	2,571	2,630
Office furniture and equipment
Property and Equipment
Total property and equipment	3,362	3,409
Leasehold Improvements
Property and Equipment
Total property and equipment	9,531	10,103
Construction in Progress
Property and Equipment
Total property and equipment	632	344
Property and equipment
Property and Equipment
Depreciation and amortization expense	$ 1,600	$ 2,000	$ 2,700

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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