Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Taxes

Schedule of components of income tax benefit (provision)

	Year Ended December 31,
	2021		2020		2019
	(In thousands)
Income tax benefit (provision):
Federal	$	18,513	$	16,615	$	13,869
State		7,082		5,802		2,170
Expiration of NOLs and R&D credit		(14,210)		(20,294)		(18,966)
		11,385		2,123		(2,927)
Deferred tax valuation allowance		(11,158)		(956)		2,927
	$	227	$	1,167	$	—

Schedule of reconciliation between the amount of reported income tax and the amount computed using the U.S. Statutory rate

	2021		2020		2019
	(In thousands)
Pre-tax loss	$	(70,738)	$	(60,947)	$	(50,878)
Loss at statutory rates		(14,855)		(12,799)		(10,684)
Research and development credits		(2,422)		(1,778)		(1,902)
State taxes		(7,082)		(5,802)		(2,170)
Other		(941)		(1,152)		(1,011)
Change in fair value remeasurement of contingent consideration		(295)		(886)		(272)
Expiration of NOLs and R&D credit		14,210		20,294		18,966
Change in valuation allowance		11,158		956		(2,927)
Income tax (benefit) provision	$	(227)	$	(1,167)	$	—

Schedule of principal components of the deferred tax assets and liabilities

	December 31,		December 31,
	2021		2020
	(In thousands)
Gross deferred tax assets
Net operating loss carryforwards	$	183,711	$	174,369
Tax credit carryforwards		47,927		44,936
Deferred research and development expenses		59,753		63,215
Stock-based compensation		14,719		13,196
Fixed assets		1,287		1,303
Accrued expenses and other		370		325
		307,767		297,344
Gross deferred tax liabilities
IPR&D intangibles		(6,840)		(7,802)
Total deferred tax assets and liabilities		300,927		289,542
Valuation allowance		(302,540)		(291,382)
Net deferred tax liability	$	(1,613)	$	(1,840)