Property and Equipment, Net (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Property and Equipment
Total property and equipment	$ 25,052	$ 32,434
Less: accumulated depreciation and amortization	(21,237)	(28,403)
Property and equipment, net	3,815	4,031
Depreciation and amortization expense	3,929	4,858	$ 3,577
Laboratory equipment
Property and Equipment
Total property and equipment	8,566	8,622
Manufacturing equipment
Property and Equipment
Total property and equipment	2,630	2,510
Office furniture and equipment
Property and Equipment
Total property and equipment	3,409	3,873
Leasehold improvements
Property and Equipment
Total property and equipment	10,103	17,238
Construction in progress
Property and Equipment
Total property and equipment	344	191
Property and equipment
Property and Equipment
Depreciation and amortization expense	$ 2,000	$ 2,700	$ 3,600

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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