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Revenue (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2014
Dec. 31, 2018
Revenue            
Contract liability $ 453   $ 453     $ 1,586
Revenues 546 $ 941 2,686 $ 7,774    
Revenue, contract liabilities 100   1,300      
Product Development and Licensing Agreements            
Revenue            
Revenues 55 131 379 2,792    
Contracts and Grants            
Revenue            
Revenues 491 810 2,307 4,982    
Bristol-Myers Squibb Company | Product Development and Licensing Agreements            
Revenue            
Revenues 0 100 200 2,700    
Revenue, contract liabilities         $ 5,000  
Reimbursement of external costs (as percent)         50.00%  
IAVI & Frontier | Contracts and Grants            
Revenue            
Revenues 100 100 300 2,800    
Rockefeller and Duke | Contracts and Grants            
Revenue            
Revenues $ 400 $ 600 $ 1,900 $ 2,100