Amount of increase (decrease) in the value of a contingent consideration liability, including, but not limited to, differences arising upon settlement.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 50
-Paragraph 4
-Subparagraph (a)(1)
-URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e7008-128479

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- Definition

For contingent consideration arrangements recognized in connection with a business combination, this element represents an estimate of the high-end of the potential range (undiscounted) of the consideration which may be paid.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 30
-Section 50
-Paragraph 1
-Subparagraph (c)(3)
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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

Amount of transfers of assets measured on a recurring basis out of Level 1 of the fair value hierarchy into Level 2.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (bb)
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Amount of transfers of assets measured on a recurring basis out of Level 2 of the fair value hierarchy into Level 1.

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Amount of transfers of liabilities measured on a recurring basis out of Level 1 of the fair value hierarchy into Level 2.

+ References

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Amount of transfers of liabilities measured on a recurring basis out of Level 2 of the fair value hierarchy into Level 1.

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Amount of transfers of financial instrument classified as a liability into level 3 of the fair value hierarchy.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
-Paragraph 2
-Subparagraph (c)(3)
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- Definition

Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(3)
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Amount of transfer of financial instrument classified as an asset into level 3 of the fair value hierarchy.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(3)
-URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258

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Amount of transfers of financial instrument classified as an asset out of level 3 of the fair value hierarchy.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
-Paragraph 2
-Subparagraph (c)(3)
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Fair Value Measurements - Additional information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Nov. 29, 2016
Fair value measurements
(Gain)/Loss on Fair Value Remeasurement of Contingent Consideration	$ (13,600)	$ 3,400
Kolltan \| Specified development, regulatory approvals or sales-based milestones
Fair value measurements
Milestone payments			$ 172,500
Fair value
Fair value measurements
Assets level 1 to level 2 transfers	0
Assets level 2 to level 1 transfers	0
Liabilities level 1 to level 2 transfers	0
Liabilities level 2 to level 1 transfers	0
Asset transfer out of level 3	0
Asset transfer into level 3	0
Liabilities transfers out of level 3	0
Liabilities transfers into level 3	$ 0