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Fair Value Measurements (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Nov. 29, 2016
Jun. 30, 2017
Jun. 30, 2017
Jun. 30, 2017
Dec. 31, 2016
Roll-forward of acquisition-related contingent consideration          
Fair value adjustments included in operating expenses   $ 1,000 $ 4,400    
Assets transferred between the fair value measurement classifications       $ 0  
Liabilities transferred between the fair value measurement classifications       0  
Kolltan          
Roll-forward of acquisition-related contingent consideration          
Maximum amount of future consideration payable $ 172,500        
Fair Value Measurements | Level 2          
Assets:          
Money market funds and cash equivalents       44,622 $ 20,445
Marketable securities       87,822 147,315
Total financial assets at fair value       132,444 167,760
Fair Value Measurements | Level 3          
Liabilities:          
Kolltan acquisition contingent consideration   48,600 44,200 48,600 44,200
Total financial liabilities at fair value       48,600 44,200
Roll-forward of acquisition-related contingent consideration          
Balance at beginning of period     44,200    
Balance at end of period   48,600 48,600    
Fair Value Measurements | Fair value          
Assets:          
Money market funds and cash equivalents       44,622 20,445
Marketable securities       87,822 147,315
Total financial assets at fair value       132,444 167,760
Liabilities:          
Kolltan acquisition contingent consideration   48,600 44,200 48,600 44,200
Total financial liabilities at fair value       48,600 44,200
Roll-forward of acquisition-related contingent consideration          
Balance at beginning of period     44,200    
Balance at end of period   48,600 48,600    
Fair Value Measurements | Fair value | Level 3          
Roll-forward of acquisition-related contingent consideration          
Fair value adjustments included in operating expenses   1,000      
Fair Value Measurements | Fair value | Level 3 | Other Long-Term Liabilities          
Liabilities:          
Kolltan acquisition contingent consideration   48,600 44,200 $ 48,600 $ 44,200
Roll-forward of acquisition-related contingent consideration          
Balance at beginning of period     44,200    
Fair value adjustments included in operating expenses     4,400    
Balance at end of period   $ 48,600 $ 48,600