CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
REVENUE:
Product Development and Licensing Agreements	$ 35	$ 14
Contracts and Grants	54
Product Royalties	2,344	2,502
Total Revenue	2,433	2,516
OPERATING EXPENSE:
Research and Development	10,769	6,853
Royalty	2,344	2,502
General and Administrative	2,317	2,336
Amortization of Acquired Intangible Assets	291	483
Total Operating Expense	15,721	12,174
Operating Loss	(13,288)	(9,658)
Investment and Other Income, Net	205	84
Interest Expense	(433)	(485)
Net Loss	(13,516)	(10,059)
Basic and Diluted Net Loss Per Common Share (Note 3) (in dollars per share)	$ (0.27)	$ (0.31)
Shares Used in Calculating Basic Net Loss per Share (Note 3) (in shares)	50,145	32,047
Shares Used in Calculating Diluted Net Loss per Share (Note 3) (in shares)	50,145	32,047
COMPREHENSIVE LOSS:
Net Loss	(13,516)	(10,059)
Other Comprehensive (Loss) Income:
Foreign Currency Translation Adjustments	2	(4)
Unrealized Gain on Marketable Securities	108	13
Comprehensive Loss	$ (13,406)	$ (10,050)