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Summary of Significant Accounting Policies - Intangible Assets (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Intangible assets      
Non-cash impairment charge, indefinite-lived   $ 18,677 $ 13,000
IPR&D      
Intangible assets      
Non-cash impairment charge, indefinite-lived $ 11,800    
License Rights      
Intangible assets      
Non-cash impairment charge, finite lived $ 6,900