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Selected Quarterly Financial Data (Unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Selected Quarterly Financial Data (Unaudited)                      
Total revenue $ 3,456 $ 3,924 $ 3,829 $ 1,534 $ 1,874 $ 2,220 $ 1,389 $ 1,303 $ 12,743 $ 6,786 $ 5,480
Net loss $ (3,841) $ (26,363) $ (28,566) $ (34,261) $ (32,307) $ (29,598) $ (31,952) $ (34,673) $ (93,031) $ (128,530) $ (127,197)
Basic and diluted net loss per common share (in dollars per share) $ (0.03) $ (0.20) $ (0.23) $ (0.28) $ (0.30) $ (0.29) $ (0.32) $ (0.35) $ (0.72) $ (1.27) $ (1.31)