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Stock-Based Compensation - Employee Stock Option and Incentive Plan Activity (Details) - 2008 Plan - Stock options - $ / shares
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Shares    
Options Outstanding at beginning of the period (in shares) 10,218,710  
Granted (in shares) 2,427,200  
Canceled (in shares) (1,789,698)  
Options Outstanding at the end of the period (in shares) 10,856,212 10,218,710
Options Vested and Expected to Vest at the end of the period (in shares) 10,780,023  
Options Exercisable at the end of the period (in shares) 6,846,254  
Shares Available for Grant (in shares) 8,324,310  
Weighted Average Exercise Price Per Share    
Options Outstanding at beginning of the period (in dollars per share) $ 11.14  
Granted (in dollars per share) 2.37  
Canceled (in dollars per share) 9.76  
Options Outstanding at the end of the period (in dollars per share) 9.40 $ 11.14
Options Vested and Expected to Vest at the end of the period (in dollars per share) 9.43  
Options Exercisable at the end of the period (in dollars per share) $ 11.18  
Weighted Average Remaining Contractual Term (In Years)    
Options Outstanding at the end of the period 6 years 1 month 6 days 6 years 6 months
Options Vested and Expected to Vest at the end of the period 6 years 1 month 6 days  
Options Exercisable at the end of the period 4 years 6 months