CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
REVENUE:
Product Development and Licensing Agreements	$ 160	$ 146	$ 110
Contracts and Grants	1,617	281	36
Product Royalties	2,334	10,775	9,119
Total Revenue	4,111	11,202	9,265
OPERATING EXPENSE:
Research and Development	67,401	47,398	32,439
Royalty	2,334	10,775	9,119
General and Administrative	14,805	10,016	9,193
Amortization of Acquired Intangible Assets	1,013	1,090	1,913
Total Operating Expense	85,553	69,279	52,664
Operating Loss	(81,442)	(58,077)	(43,399)
Investment and Other Income, Net	819	530	396
Interest Expense	(927)	(1,576)	(1,796)
Net Loss	(81,550)	(59,123)	(44,799)
Basic and Diluted Net Loss Per Common Share (Note 2) (in dollars per share)	$ (1.02)	$ (1.02)	$ (1.13)
Shares Used in Calculating Basic and Diluted Net Loss per Share (Note 2) (in shares)	79,777	57,713	39,501
COMPREHENSIVE LOSS:
Net Loss	(81,550)	(59,123)	(44,799)
Other Comprehensive Income (Loss):
Foreign Currency Translation Adjustments	(3)	2	(9)
Unrealized (Loss) Gain on Marketable Securities	(74)	91	(90)
Comprehensive Loss	$ (81,627)	$ (59,030)	$ (44,898)