INCOME TAXES (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended								12 Months Ended
	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Income tax benefit (provision):
Federal									$ 19,394	$ 16,204	$ 1,512
State									4,237	3,131	779
Foreign										84	107
Expiration of Net Operating Losses and Research & Development Tax Credits									(1,426)	(411)	(13,924)
Income tax benefit (provision) attributable to continuing operations									22,205	19,008	(11,526)
Deferred tax valuation allowance									(22,205)	(19,008)	11,526
Income tax benefit (provision)									0
Reconciliation between the amount of reported income tax and the amount computed using U.S. Statutory rate
U.S. Statutory rate (as a percent)									34.00%
Pre-tax loss	(16,807)	(15,027)	(13,773)	(13,516)	(12,732)	(11,772)	(10,236)	(10,059)	(59,123)	(44,799)	(2,533)
Loss at Statutory Rates									(20,102)	(15,213)	(838)
Research and Development Credits										(1,736)	(1,498)
State Taxes									(4,237)	(3,131)	(779)
Other									708	661	717
Expiration of Net Operating Losses and Research & Development Tax Credits									1,426	411	13,924
Change in Valuation Allowance									22,205	19,008	(11,526)
Income tax benefit (provision)									0
Gross Deferred Tax Assets
Net Operating Loss Carryforwards	67,728				58,802				67,728	58,802
Tax Credit Carryforwards	20,692				20,285				20,692	20,285
Deferred Expenses	43,226				31,002				43,226	31,002
Stock-based Compensation	3,264				3,184				3,264	3,184
Fixed Assets	2,156				2,029				2,156	2,029
Accrued Expenses and Other	241				197				241	197
Gross Deferred Tax Assets	137,307				115,499				137,307	115,499
Gross Deferred Tax Liabilities
Other Acquired Intangibles	(4,481)				(4,878)				(4,481)	(4,878)
IPR&D Intangibles	(4,661)				(4,661)				(4,661)	(4,661)
Gross Deferred Tax Liabilities	(9,142)				(9,539)				(9,142)	(9,539)
Total Deferred Tax Assets and Liabilities	128,165				105,960				128,165	105,960
Deferred Tax Assets Valuation Allowance	(132,826)				(110,621)				(132,826)	(110,621)
Net Deferred Tax Asset (Liability)	$ (4,661)				$ (4,661)				$ (4,661)	$ (4,661)