INTANGIBLE ASSETS AND GOODWILL (Details) (USD $)	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Intangible Assets and Goodwill
Goodwill	$ 8,965,000	$ 8,965,000
Finite-lived intangible asset
Accumulated Amortization	(3,763,000)	(3,325,000)
Total Intangible Assets
Cost of total intangible assets	27,596,000	28,248,000
Net total intangible assets	23,833,000	24,923,000
Amortization expense for intangible assets	1,090,000	1,913,000	3,143,000
Estimated future amortization expense of intangible assets
2013	1,000,000
2014	1,000,000
2015	1,000,000
2016	1,000,000
2017	900,000
Amgen Amendment
Finite-lived intangible asset
Estimated Life	16 years
Cost	14,500,000	14,500,000
Accumulated Amortization	(2,915,000)	(2,018,000)
Net	11,585,000	12,482,000
Core Technology
Finite-lived intangible asset
Estimated Life	11 years
Cost	1,296,000	1,948,000
Accumulated Amortization	(848,000)	(1,307,000)
Net	448,000	641,000
IPR&D
Indefinite-lived intangible assets:
Indefinite-lived intangible assets	$ 11,800,000	$ 11,800,000