CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
REVENUE:
Product Development and Licensing Agreements	$ 146	$ 110	$ 40,187
Contracts and Grants	281	36	220
Product Royalties	10,775	9,119	6,386
Total Revenue	11,202	9,265	46,793
OPERATING EXPENSE:
Research and Development	47,398	32,439	27,650
Royalty	10,775	9,119	12,077
General and Administrative	10,016	9,193	10,378
Amortization of Acquired Intangible Assets	1,090	1,913	3,143
Total Operating Expense	69,279	52,664	53,248
Operating Loss	(58,077)	(43,399)	(6,455)
Investment and Other Income, Net	530	396	5,259
Interest Expense	(1,576)	(1,796)	(1,337)
Net Loss	(59,123)	(44,799)	(2,533)
Basic and Diluted Net Loss Per Common Share (See Note 2) (in dollars per share)	$ (1.02)	$ (1.13)	$ (0.08)
Shares Used in Calculating Basic and Diluted Net Loss per Share (See Note 2) (in shares)	57,713	39,501	31,868
COMPREHENSIVE LOSS:
Net Loss	(59,123)	(44,799)	(2,533)
Other Comprehensive Income (Loss):
Foreign Currency Translation Adjustments	2	(9)	2
Unrealized Gain (Loss) on Marketable Securities	91	(90)	203
Comprehensive Loss	$ (59,030)	$ (44,898)	$ (2,328)