CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $) In Thousands, except Share data, unless otherwise specified	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income	Accumulated Deficit
Balance at Dec. 31, 2008	$ 18,134	$ 16	$ 136,661	$ 2,606	$ (121,149)
Balance (in shares) at Dec. 31, 2008		15,789,756
Increase (Decrease) in Stockholders' Equity
Shares Issued under Stock Option and Employee Stock Purchase Plans	917		917
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares)		172,592
Shares Issued in Connection with the CuraGen acquisition	88,243	16	88,227
Shares Issued in Connection with the CuraGen acquisition (in shares)		15,722,713
Share-Based Compensation	3,058		3,058
Foreign Currency Translation Adjustments	(12)			(12)
Unrealized (Loss) Gain on Marketable Securities	(48)			(48)
Net Loss	(36,525)				(36,525)
Balance at Dec. 31, 2009	73,767	32	228,863	2,546	(157,674)
Balance (in shares) at Dec. 31, 2009		31,685,061
Increase (Decrease) in Stockholders' Equity
Shares Issued under Stock Option and Employee Stock Purchase Plans	1,014		1,014
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares)		370,321
Share-Based Compensation	2,802		2,802
Foreign Currency Translation Adjustments	2			2
Unrealized (Loss) Gain on Marketable Securities	203			203
Net Loss	(2,533)				(2,533)
Balance at Dec. 31, 2010	75,255	32	232,679	2,751	(160,207)
Balance (in shares) at Dec. 31, 2010	32,055,382	32,055,382
Increase (Decrease) in Stockholders' Equity
Shares Issued under Stock Option and Employee Stock Purchase Plans	173		173
Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares)		80,254
Shares Issued in Connection with Cantor Agreement	2,155	1	2,154
Shares Issued in Connection with Cantor Agreement (in shares)		575,000
Shares Issued in Underwritten Offering	33,695	11	33,684
Shares Issued in Underwritten Offering (in shares)		11,500,000
Share-Based Compensation	2,342		2,342
Foreign Currency Translation Adjustments	(9)			(9)
Unrealized (Loss) Gain on Marketable Securities	(90)			(90)
Net Loss	(44,799)				(44,799)
Balance at Dec. 31, 2011	$ 68,722	$ 44	$ 271,032	$ 2,652	$ (205,006)
Balance (in shares) at Dec. 31, 2011	44,210,636	44,210,636