CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
REVENUE:
Product Development and Licensing Agreements	$ 110	$ 40,187	$ 5,662
Contracts and Grants	36	220	1,802
Product Royalties	9,119	6,386	7,716
Total Revenue	9,265	46,793	15,180
OPERATING EXPENSE:
Research and Development	32,439	27,650	26,169
Royalty	9,119	12,077	8,397
Gain on Sale of Assets	(50)	(50)	(604)
General and Administrative	9,243	10,428	17,119
Amortization of Acquired Intangible Assets	1,913	3,143	949
Total Operating Expense	52,664	53,248	52,030
Operating Loss	(43,399)	(6,455)	(36,850)
Investment and Other Income, Net	396	5,259	248
Interest Expense	(1,796)	(1,337)	(452)
Net Loss Before Income Taxes	(44,799)	(2,533)	(37,054)
Income Tax Benefit			529
Net Loss	(44,799)	(2,533)	(36,525)
Basic and Diluted Net Loss Per Common Share (See Note 2) (in dollars per share)	$ (1.13)	$ (0.08)	$ (1.84)
Shares Used in Calculating Basic Net Loss per Share (See Note 2) (in shares)	39,501	31,868	19,823
Shares Used in Calculating Diluted Net Loss per Share (See Note 2) (in shares)	39,501	31,868	19,823
COMPREHENSIVE LOSS:
Net Loss	(44,799)	(2,533)	(36,525)
Other Comprehensive (Loss) Income:
Foreign Currency Translation Adjustments	(9)	2	(12)
Unrealized (Loss) Gain on Marketable Securities	(90)	203	(48)
Comprehensive Loss	$ (44,898)	$ (2,328)	$ (36,585)