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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 L204cljZBSLZWDBurzUxnY++7I65MbpLs/cHkhspb+YCKs5t/1D8OlJivyYaEjv4
 I5uf/qgal3igAl5w4YhzSQ==

<SEC-DOCUMENT>0001005477-08-002263.txt : 20080317
<SEC-HEADER>0001005477-08-002263.hdr.sgml : 20080317
<ACCEPTANCE-DATETIME>20080317193743
ACCESSION NUMBER:		0001005477-08-002263
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080307
FILED AS OF DATE:		20080317
DATE AS OF CHANGE:		20080317

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Marucci Anthony S
		CENTRAL INDEX KEY:			0001429933

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-15006
		FILM NUMBER:		08694588

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(781) 433-0771

	MAIL ADDRESS:	
		STREET 1:		66 COLD HILL DRIVE
		CITY:			MENDAHM
		STATE:			NJ
		ZIP:			07945

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AVANT IMMUNOTHERAPEUTICS INC
		CENTRAL INDEX KEY:			0000744218
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				133191702
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		119 FOURTH AVE
		CITY:			NEEDHAM
		STATE:			MA
		ZIP:			02494
		BUSINESS PHONE:		7814330771

	MAIL ADDRESS:	
		STREET 1:		119 FOURTH AVE
		CITY:			NEEDHAM
		STATE:			MA
		ZIP:			021942725

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	T CELL SCIENCES INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgar123.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-03-07</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000744218</issuerCik>
        <issuerName>AVANT IMMUNOTHERAPEUTICS INC</issuerName>
        <issuerTradingSymbol>AVAN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001429933</rptOwnerCik>
            <rptOwnerName>Marucci Anthony S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>66 COLD HILL ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MENDHAM</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07945</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Exec. VP &amp; Corporate Dev.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>8.16</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2008-03-07</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-03-07</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>254243</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">As of March 7, 2008 (the &quot;Effective Date&quot;), Anthony S. Marucci beneficially owns options to purchase 254,243 shares of common stock, par value $0.001 per share (the &quot;Shares&quot;), of AVANT Immunotherapeutics, Inc.  Options to purchase 157,093 Shares are exercisable as of the Effective Date with one twenty-fourth (1/24) of the remaining options becoming exercisable each subsequent month following the Effective Date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Anthony S. Marucci</signatureName>
        <signatureDate>2008-03-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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