Stock Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2015

Stock Incentive Plans [Abstract]

Schedule of stock-based compensation expense

	Year Ended December 31,
(In thousands)	2014		2015
Research and development	$	48	$	42
General and administrative		229		462
Total	$	277	$	504

Schedule of stock option activity

	Year Ended December 31,
	2014					2015
	Shares			Weighted Average Exercise Price		Shares		Weighted Average Exercise Price
Outstanding on January 1		284,829		$	39.46		1,084,106	$	5.52
Issued		1,039,000			1.07		232,000		0.63
Forfeited/expired		(239,723	)		18.02		-		-
Outstanding on December 31		1,084,106		$	5.52		1,316,106	$	4.66
Exercisable as of December 31		179,106		$	28.06		750,356	$	7.44

Schedule of summary of additional information on stock options outstanding

	Options Outstanding						Options Exercisable
Range of Exercise Prices	Number Outstanding		Weighted-Average Remaining Contractual Life (Years)		Weighted Average Exercise Price		Number Exercisable		Weighted Average Exercise Price
$0.63 - 0.82		252,000		4.00	$	0.65		136,000	$	0.66
$1.07 - $2.20		1,021,500		7.49		1.07		571,750		1.07
$47.60 - $87.60		21,000		2.44		67.60		21,000		67.60
$127.60 - $207.60		21,500		2.44		158.30		21,500		158.30
$526.40		106		1.10		526.40		106		526.40
Totals		1,316,106		6.66	$	4.66		750,356	$	7.44
	Weighted-Average Exercisable Remaining Contractual Life (Years)									5.84