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Accrued Expenses (Tables)
12 Months Ended
Dec. 31, 2015
Payables and Accruals [Abstract]  
Schedule of summary of major components of accrued expenses balance
  Year Ended December 31,  
(in thousands)   2014     2015  
Corporate legal fees   $ 564     $ 927  
Audit, tax and filing services     189       78  
Board fees     45       136  
Sublicense fees     125       103  
Other miscellaneous     149       52  
    $ 1,072     $ 1,296