Stock Incentive Plans (Tables)

6 Months Ended

12 Months Ended

Jun. 30, 2015

Dec. 31, 2014

Stock Incentive Plans [Abstract]

Schedule of stock-based compensation expense

	Three months ended June 30,				Six months ended June 30,
(In thousands)	2014		2015		2014		2015
Research and development	$	10	$	5	$	20	$	31
General and administrative		10		112		20		265
Total	$	20	$	117	$	40	$	296

	Year Ended December 31,
(In thousands)	2013		2014
Research and development	$	53	$	48
General and administrative		82		229
Total	$	135	$	277

Schedule of stock option activity

	Options Outstanding
	Shares		Weighted Average  Exercise Price
Outstanding, December 31, 2014		1,084,106	$	5.52
Options Issued		232,000	$	0.63
Outstanding, June 30, 2015		1,316,106	$	4.66
Exercisable, June 30, 2015		293,856	$	17.34

	Year Ended December 31,
	2013				2014
	Shares		Weighted Average Exercise Price		Shares			Weighted Average Exercise Price
Outstanding on January 1		284,829	$	39.46		284,829		$	39.46
Issued		-		-		1,039,000			1.07
Forfeited/Expired		-		-		(239,723	)		18.02
Outstanding on December 31		284,829	$	39.46		1,084,106		$	5.52
Exercisable as of December 31		246,559	$	45.28		179,106		$	28.06

Schedule of summary of additional information on stock options outstanding

	Options Outstanding						Options Exercisable
			Weighted-Average
			Remaining						Weighted
Range of Exercise	Number		Contractual Life		Weighted Average		Number		Average
Prices	Outstanding		(Years)		Exercise Price		Exercisable		Exercise Price
$0.63 - $0.82		252,000		4.50	$	0.65		126,000	$	0.65
$0.83 - $1.07		1,019,000		8.00		1.07		124,000		1.07
$1.08 - $2.20		2,500		6.19		2.20		1,250		2.20
$2.21 - $50.00		10,500		2.95		47.60		10,500		47.60
$50.01 - $100.00		10,500		2.95		87.60		10,500		87.60
$100.01 - $200.00		16,000		2.95		141.35		16,000		141.35
$200.01 - $526.40		5,606		2.92		213.63		5,606		213.63
Totals		1,316,106		7.16	$	4.66		293,856	$	17.34
Weighted-Average Exercisable Remaining Contractual Life (Years)										4.16

		Options Outstanding						Options Exercisable
Range of Exercise Prices		Number Outstanding		Weighted-Average Remaining Contractual Life (Years)		Weighted Average Exercise Price		Number Exercisable		Weighted Average Exercise Price
$0.82			20,000		4.80	$	0.82		10,000	$	0.82
$1.07			1,019,000		8.49		1.07		124,000		1.07
$2.00 - $2.20			2,500		6.70		2.20		2,500		2.20
$11.60 - $50.00			10,500		3.44		47.60		10,500		47.60
$50.00 - $90.80			10,500		3.40		87.60		10,500		87.60
$127.60 - $207.60			21,500		3.40		158.30		21,500		158.30
$420.00 - $588.80			106		2.10		526.40		106		526.40
Totals			1,084,106		8.23	$	5.52		179,106	$	28.06
	Weighted-Average Exercisable Remaining Contractual Life (Years)										4.44