Stock Incentive Plans (Tables)

3 Months Ended

Mar. 31, 2013

Stock Incentive Plans [Abstract]

Schedule of stock-based compensation expense

	Three months ended March 31,
(In thousands)	2012		2013
Research and development	$	113	$	11
General and administrative		116		18
Total	$	229	$	29

Schedule of stock option activity

	2012					2013
				Weighted				Weighted
				Average				Average
				Exercise				Exercise
	Shares			Price		Shares		Price
Outstanding on January 1		576,773		$	26.16		284,829	$	39.46
Forfeitures and expirations		(41,181	)		15.20		-		-
Outstanding on March 31		535,592		$	27.09		284,829	$	39.46
Exercisable as of March 31		188,937		$	71.41		203,112	$	54.19

Schedule of summary of additional information on stock options outstanding

	Options Outstanding						Options Exercisable
			Weighted-Average		Weighted				Weighted
			Remaining		Average				Average
Range of Exercise	Number		Contractual Life		Exercise		Number		Exercise
Prices	Outstanding		(Years)		Price		Exercisable		Price
$2.00 - $2.20		154,288		8.42	$	2.02		75,571	$	2.02
$11.60 - $24.50		11,175		7.26		22.44		8,175		21.69
$29.82 - $90.80		84,694		5.64		61.40		84,694		61.40
$127.60 - $167.60		28,166		5.21		136.60		28,166		136.60
$207.60 - $588.80		6,506		4.79		250.55		6,506		250.55
Totals		284,829		7.14	$	39.46		203,112	$	54.19
Exercisable		203,112		6.64